CM from <i>L. plantarum</i> (Lp CM) and <i>L. acidophilus</i> and <i>B. infantis</i> (La/Bi CM) inhibited proteasome activity.

<p>CM inhibited proteasome activity in the experimental intestinal injury model. At the end of each experiment, liver was harvested, lysed, and proteasome was purified and subjected to a proteasome chymotrypsin-like activity assay as described in “Materials and Methods”. Five µM of the proteasome specific inhibitor epoxomicin (Epox) was added in separate wells as a control to confirm specificity of the assay. Proteasome chymotrypsin-like activity was determined by the rate of generation of fluorogenic product over time. Five µM of Epox was added in separate wells as a control to confirm specificity of the assay. Data (n = 4) are presented as mean ± SE. “*” and “**” depict p<0.05 and 0.001 compared to vehicle groups, respectively, by one-way ANOVA with Bonferroni correction.