Macular hole case 2.

<p>Images of the left eye of a 62-year-old woman with stage 3 idiopathic MH with a Snellen equivalent BCVA of 20/100. <b>A</b>, SD-OCT shows a full-thickness MH. The IS/OS junction line is diminished in the area indicated by arrowheads. a: minimum diameter of MH, b: basal diameter of MH, c: MH height. Scale bar = 1000 µm. <b>B–I</b>, Images taken 1 year after surgery, by which time BCVA was 20/70. <b>B</b>, Fundus photography shows a closed MH. <b>C</b>, Infrared image with green arrows indicating the directions of the scans producing the images in E and F, and a white box indicating the size of the double-headed arrows in E and F. <b>D</b>, Microperimetry shows central scotoma. <b>E</b> and <b>F</b>, SD-OCT images. <b>E</b>, A horizontal-line scan through the center of the fovea, taken in the direction of the horizontal arrow in C, revealing disruptions of the IS/OS junction (between blue arrowheads). A moderately reflective lesion is seen in the fovea (asterisk). ELM: external limiting membrane, ONL: outer nuclear layer, RPE: retinal pigment epithelium. Scale bar = 1000 µm. <b>F</b>, A vertical-line scan through the center of the fovea, in the direction of the vertical arrow in C, demonstrating disruptions of the IS/OS junction (between blue arrowheads). A moderately reflective lesion is seen in the fovea (asterisk). Scale bar = 1000 µm. <b>G</b>, AO-SLO images of the area indicated by a white box in C and the double-headed arrows in E and F showing large dark regions (yellow arrows). Dark regions, which are seen all over the fovea, correspond to the area of IS/OS junction disruption on SD-OCT (E and F). Scale bar = 200 µm. <b>H</b>, A high-magnification view that includes the foveola. <b>I</b>, Automated detection of cone loss area. The circle indicates the foveola. Dim pixels with its reflectivity below the threshold are shown in green and red depending on whether they are located inside or outside of the circle, respectively. Cone loss ratio in the foveola was 68.26%.