Phosphorylation of rpS6 at Ser235/236 in the hippocampus upon kainic acid-induced status epilepticus and rapamycin treatment.

<p>(<b><i>A</i></b>) Representative images of hippocampal sections immunohistochemically stained for P-S6 in control animals and in animals 2 and 24 h after kainic acid (KA) injection. Panels on the right represent higher-magnification of hippocampal regions boxed on the major view (left panels). (<b><i>B</i></b>) Representative images of hippocampal sections immunohistochemically stained for P-S6 in rapamycin- and rapamycin+KA-treated animals 2 and 24 h after KA treatment. Panels on the right represent higher-magnification of hippocampal regions boxed on the major view (left panel). RA – chronic rapamycin treatment. Arrows point to P-S6-positive neuronal-like cells. Arrowheads show glial-like P-S6-immunoreactive cells. Scale bar = 200 µm (left panel). Scale bar = 20 µm (right panel).