Long-term potentiation (LTP) in hippocampal brain slices of anesthetized and sham-treated mice was not different.

<p>24 h after sevoflurane anesthesia (sev) or sham treatment (sham), brain slices of the animals were prepared and hippocampal LTP was assessed as elevation of field excitatory postsynaptic potential slopes (fEPSP slopes) after high frequency stimulation (HFS). HFS led to an LTP of fEPSP slopes, which was not significantly different between the two groups. Each symbol represents the averaged fEPSP slopes normalized with respect to the 5 min baseline period before HFS. Insets show fEPSP recordings before and 40 min after HFS.