CGZ increases p-JNK levels on primary hippocampal neurons.

<p>Cultured hippocampal neurons (15 DIV) were treated with CGZ and GW for 72 h, and cells extracts were prepared for p-JNK and total JNK protein levels detection by western blot. Quantification of 4 independent experiments showed that CGZ increased p-JNK levels with not apparent effect on total JNK. Inhibition of PPARγ with GW prevented the increase of p-JNK induced by CGZ. Data are the mean ± S.E.M. of 4 independent experiments. *p<0.05 show significant differences between untreated compared with CGZ or CGZ plus GW treated neurons.