Serum titers and seropositive levels in mice receiving varying doses of COPS:FliC.

<p>Mice were immunized with PBS or three doses of the indicated amount of COPS:FliC. Serum was obtained 21 days after the third dose, and levels of specific antibody in individual mice (grey diamonds), and the geometric mean titer (black rectangles) and percent seropositive (white rectangles) within groups were determined by ELISA for A. FliC, or B. LPS. Statistical significance (P values) for COPS:FliC immunized groups relative to PBS controls assessed by Mann-Whitney rank sum test are indicated.