Tumor growth (mm³) in PyVT male mice treated with tamoxifen.

<p>Tumors measured in two dimensions with calipers every 2 days prior to administration of treatment during early tumor development. A) The tumor size is expressed over the 14 day treatment period for the DMSO (control) and tamoxifen (40 mg/kg) treated PyVT mice. Days 0–12 represent the days of the 7 IP injections, day 14 represents the end of the study with measurements prior to tissue harvest. B) The overall change in tumor size after treatment with DMSO (control) or tamoxifen (40 mg/kg) via 7 IP injections. C) Number of developed tumors per PyVT male mouse during development. Tumors identified grossly during the early stage of tumor development after a 14 day period with either treatment with DMSO (control) or tamoxifen (40 mg/kg) via 7 IP injections. *P-value <0.05 compared to control.