Reduction of HCV(1b/2a) levels by anti-CD81 Ab alone and in combination with BILN-2061 or BMS-790052.

<p>HCV(1b/2a) persistently-infected cell cultures were treated with 5×EC₅₀ concentrations of the indicated HCV inhibitors for 21 days (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065273#pone-0065273-t001" target="_blank">Table 1</a> and Materials and Methods). HCV levels were normalized relative to the level of the DMSO control at each time point. This data is the average of 3 assays. Error bars represent standard deviation. Asterisks indicate statistically significant differences at day 21 from the DMSO day 21 time point (<i>t</i> test P≤0.05). (A) DMSO (solid circles and solid line), anti-CD81 Ab (pierced circles and dashed line), BILN-2061 (solid squares and dashed line), BMS-790052 (pierced squares and solid line), BILN-2061/anti-CD81 Ab (solid diamonds and solid line), BMS-790052/anti-CD81 Ab (solid hexagons and solid line), and BILN 2061/BMS-790052 (pierced diamonds and dashed line).