Antifibrotic effect of FK506 in alcohol model of hepatic fibrosis.

<p>A. Masson's trichrome staining of the liver sections from rats treated for 4 weeks as indicated. Two livers of each treatment group are shown at 100× magnification. B. 500× magnification of the squared sections in A. C. Percentage of liver fibrosis was determined from the Masson's trichrome staining using ImageJ software and plotted as percent fibrotic area vs. total liver area. Data represents average and±1 SEM from 8 rats, *** represents significance at p<0.01. D. and E. Aminotransferases in plasma of the experimental animals. The activity is presented as average and±1 SEM of 8 animals analyzed in duplicate.