Depletion of intestinal LTi-like cells increases susceptibility to <i>S.</i> Typhimurium infection.

<p>(A) Scatter plot demonstrating depletion of colonic IL-1R1⁺ CD4⁺ Lin⁻ LTi-like cells by injection of anti-CD4 antibodies. Number of CD4⁺ cells (<i>top</i>) and LTi-like cells (<i>bottom</i>) isolated from cLP of Rag1^−/− C57BL/6J mice is indicated. Data shown are representative of three experiments. (B-D) Weights (normalized to starting weight) (B), survival (C), and fecal burden of <i>S.</i> Typhimurium (D) over time following <i>S.</i> Typhimurium infection in isotype control (<i>square</i>) and anti-CD4 (αCD4; <i>triangle</i>) antibody-treated mice. (E) CFUs of <i>S.</i> Typhimurium in the liver or spleen at time of death in isotype control- and αCD4-treated mice. (F) Histological scores for the cecum and proximal colon in isotype control- and αCD4-treated mice. *, <i>p</i><0.05; **, <i>p</i><0.01; NS, not significant.