Effect of <i>Shigella</i> strains on the fecal microbiota in cynomolgus macaques.

<p>Community type composition, clinical disease symptoms, and elicited immune response over time for (<b>A</b>) study 1, (<b>B</b>) study 2, (<b>C</b>), study 3, and (<b>D</b>) study 4. Individual macaque identification and treatment administered (CVD1255, CVD1256 or PBS) are indicated on the y-axis (left), with geographic origin of each macaque on the right. Sampling day is indicated on the x-axis, with color-coded arrows (immunization or challenge) indicating time of treatment (boxed inset). Community type (<b>A</b>–<b>D</b>) is indicated on the first top bar, stool severity score ranging from 1 (mild) to 4 (severe) (<b>A</b> to <b>C</b>) is indicated on the second bar, and anti-LPS IgA and anti-LPS IgG fold differences over antibody levels before immunization and challenge (day 0) (<b>A</b>–<b>C</b>) are indicated on the third and fourth (bottom) bars, respectively, each color-coded according to the boxed inset, with day 0 antibody titers shown the same as <4 fold increases.