<p>(A) Expression of an <i>Nxt1</i> RNAi hairpin construct in the male germline causes a highly penetrant meiotic arrest phenotype. (B) Q-RT-PCR reveals that expression of <i>Nxt1</i> target genes is reduced in <i>Nxt1</i> RNAi testes (dark bars), and that the effect is similar to that seen in <i>Nxt1<sup>z2-0488</sup></i>/<i>Nxt1<sup>DG05102</sup></i> mutant testes (light bars).</p
<p>(A) Top: Intron-exon structure of the <i>nup98-96</i> locus. Coding region in dark grey. Gene pro...
Male infertility caused by a maturation arrest of spermatogenesis is a condition with an abrupt stop...
<p><b>(A)</b> A heatmap showing log2 fold change in differentially expressed genes in spermatocytes ...
<p>Comparison of gene expression defects in Nxt1, <i>aly</i> (<i>aly</i>-class mutant) and <i>nht</i...
<p>(A) All stages of spermatogenesis are seen in wild type testes by phase contrast microscopy. Larg...
<p>(A) Expression of nascent (unspliced) RNA was quantified using primer pairs a+c, b+c or b+d, whil...
<p>RNA in situ hybridisation reveals CG42355-LacZ reporter construct expression in control testes, a...
<p>(A) Testes were isolated from males without (+) or with spermatocyte-specific THR depletion by tr...
DNA mismatch repair (MMR) genes have been described to participate in crossover events during meioti...
International audienceGene expression in meiotic cells in the testis is characterized by intense tra...
Two percent of human males are infertile because of severe defects in sperm production. In the clini...
<p>(A) Targeted inactivation of the <i>Morc2b</i> gene. Deletion of exon 2 removes the entire coding...
The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence s...
The highly conserved, Nxf/Nxt (TAP/p15) RNA nuclear export pathway is important for export of most m...
<p><b>(A)</b> Schematic of sexual <i>S</i>. <i>mediterranea</i> and magnified section of a planarian...
<p>(A) Top: Intron-exon structure of the <i>nup98-96</i> locus. Coding region in dark grey. Gene pro...
Male infertility caused by a maturation arrest of spermatogenesis is a condition with an abrupt stop...
<p><b>(A)</b> A heatmap showing log2 fold change in differentially expressed genes in spermatocytes ...
<p>Comparison of gene expression defects in Nxt1, <i>aly</i> (<i>aly</i>-class mutant) and <i>nht</i...
<p>(A) All stages of spermatogenesis are seen in wild type testes by phase contrast microscopy. Larg...
<p>(A) Expression of nascent (unspliced) RNA was quantified using primer pairs a+c, b+c or b+d, whil...
<p>RNA in situ hybridisation reveals CG42355-LacZ reporter construct expression in control testes, a...
<p>(A) Testes were isolated from males without (+) or with spermatocyte-specific THR depletion by tr...
DNA mismatch repair (MMR) genes have been described to participate in crossover events during meioti...
International audienceGene expression in meiotic cells in the testis is characterized by intense tra...
Two percent of human males are infertile because of severe defects in sperm production. In the clini...
<p>(A) Targeted inactivation of the <i>Morc2b</i> gene. Deletion of exon 2 removes the entire coding...
The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence s...
The highly conserved, Nxf/Nxt (TAP/p15) RNA nuclear export pathway is important for export of most m...
<p><b>(A)</b> Schematic of sexual <i>S</i>. <i>mediterranea</i> and magnified section of a planarian...
<p>(A) Top: Intron-exon structure of the <i>nup98-96</i> locus. Coding region in dark grey. Gene pro...
Male infertility caused by a maturation arrest of spermatogenesis is a condition with an abrupt stop...
<p><b>(A)</b> A heatmap showing log2 fold change in differentially expressed genes in spermatocytes ...