Effect of the overexpression of Mfn2 or the truncated Mfn2 mutant on mitochondrial function in GCDCA-treated L02 cells.

<p>The overexpression of Mfn2 or truncated Mfn2 (A) protected cell viability in L02 cells, (B) reversed the reduction in ATP levels, (C) ameliorated the decrease in ΔΨm, and (D) reduced the excess ROS production following treatment with GCDCA. The results are expressed as a percentage of the control value, which was set at 100%. The values are the means ± SEM. *P<0.05 versus the control group, <b>^#</b>P<0.05, <b>^##</b>P<0.01 versus the GCDCA group, n = 6.