Effect of chronic propranolol treatment on spatial memory and neuropathology in Tg2576 mice.

<p>(A-D) The influence of chronic propranolol treatment on Aβ related spatial memory in Tg2576 mice by Morris water maze test (A) Visible trial (B) Swimming speed (C) Hidden platform learning acquisition, latency score represents time taken to escape to the platform from the water. (D) Probe trial. Percent of time in quadrant is calculated as the ratio of time spent in the target quadrant area relative to the time spent in the rest of the pool. (E-F) The influence of chronic propranolol treatment wild type mice by Morris water maze test: (E) Hidden platform learning acquisition (F) Probe trial. (G-H) Brain and plasma levels of total Aβ1-40 and Aβ1-42 peptides following chronic propranolol treatment. Values represent group mean ± SEM, n = 7–8 per group.