<p>In super-shedders, high levels of <i>Salmonella</i> in the gastrointestinal tract induce systemic neutrophilia with extensive granulopoiesis occurring in the bone marrow, resulting in elevated neutrophil counts in the blood, GI tract and spleen. This is accompanied by dampened IL-2 and IL-6 cytokine responsiveness in splenic CD4 T cells, fewer T<sub>H</sub>1 cells and more T<sub>regs</sub>. In moderate shedders, low levels of gastrointestinal <i>Salmonella</i> induce very few neutrophils systemically, leading to an active IL-2 and IL-6 response with increased T<sub>H</sub>1 cells and fewer T<sub>regs</sub>. Induction of granulopoiesis in moderate-shedders results in the super-shedder immune phenotype with the exception of T<sub>regs</sub...
The generation of immune cells from BM precursors is a carefully regulated process. This is essentia...
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a food-borne pathogen that causes severe...
Salmonella typhi is the causative organism for typhoid fever, a serious systemic disease in humans. ...
<div><p>Host-to-host transmission of a pathogen ensures its successful propagation and maintenance w...
Host-to-host transmission of a pathogen ensures its successful propagation and maintenance within a ...
Gastrointestinal infections with Salmonella enterica serovars have different clinical outcomes that ...
<p>Summary of the results in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal....
Mice lacking B cells are more susceptible to S. typhimurium infection. How B cells contribute to pro...
Neutrophils are innate immune response cells designed to kill invading microorganisms. One of the me...
Salmonella enterica, a Gram-negative pathogen, causes a spectrum of human infections including enter...
This study examines innate immunity to oral Salmonella during primary infection and after secondary ...
Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defe...
Neutrophils are innate immune response cells designed to kill invading microorganisms. One of the me...
SummaryReactive oxygen and nitrogen species function in host defense via mechanisms that remain cont...
<p><b>A</b>) Polymorphonuclear neutrophils (PMN, magenta) accumulate close to <i>Salmonella</i> (yel...
The generation of immune cells from BM precursors is a carefully regulated process. This is essentia...
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a food-borne pathogen that causes severe...
Salmonella typhi is the causative organism for typhoid fever, a serious systemic disease in humans. ...
<div><p>Host-to-host transmission of a pathogen ensures its successful propagation and maintenance w...
Host-to-host transmission of a pathogen ensures its successful propagation and maintenance within a ...
Gastrointestinal infections with Salmonella enterica serovars have different clinical outcomes that ...
<p>Summary of the results in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal....
Mice lacking B cells are more susceptible to S. typhimurium infection. How B cells contribute to pro...
Neutrophils are innate immune response cells designed to kill invading microorganisms. One of the me...
Salmonella enterica, a Gram-negative pathogen, causes a spectrum of human infections including enter...
This study examines innate immunity to oral Salmonella during primary infection and after secondary ...
Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defe...
Neutrophils are innate immune response cells designed to kill invading microorganisms. One of the me...
SummaryReactive oxygen and nitrogen species function in host defense via mechanisms that remain cont...
<p><b>A</b>) Polymorphonuclear neutrophils (PMN, magenta) accumulate close to <i>Salmonella</i> (yel...
The generation of immune cells from BM precursors is a carefully regulated process. This is essentia...
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a food-borne pathogen that causes severe...
Salmonella typhi is the causative organism for typhoid fever, a serious systemic disease in humans. ...