Distinct systemic immune profiles associated with fecal shedding states.

<p>Summary of the results in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003408#ppat-1003408-g001" target="_blank">Figures 1</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003408#ppat-1003408-g002" target="_blank">2</a> presenting a super-shedder immune state that is distinct from the moderate-shedder immune state in the parameters mentioned. It should be noted that the plus signs indicate greater frequency of the cell type or better cytokine responsiveness with respect to uninfected mice. Thus while moderate-shedders have high levels of splenic neutrophils (+) compared to uninfected mice, they have fewer neutrophils compared to super-shedder mice (+++). Similarly, the frequency of T_regs decreases during infection compared to uninfected. Thus, moderate shedders have fewer T_regs (−−−) compared to super-shedders (−).