Metal-Free Synthesis of 2‑Aminobenzothiazoles via Aerobic Oxidative Cyclization/Dehydrogenation of Cyclohexanones and Thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-<i>d</i>]thiazoles, and 2-aminonaphtho[1,2-d]thiazoles were prepared via this method in satisfactory yields