<p>Chemokine transcript levels (<b>A–D</b>) and protein levels (<b>E–H</b>) in WT and <i>tlr3</i><sup>−/−</sup> livers homogenates after APAP. The data represent mean±SEM obtained from 2–3 independent experiments (<i>n</i> = 5/group). *p<0.05; **p<0.01 and ***p<0.001 when WT were compared with <i>tlr3</i><sup>−/−</sup> mice.</p
International audienceTLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrot...
<p>FTIR spectra (950 cm<b><sup>−</sup></b><sup>1</sup> to 1200 cm<b><sup>−</sup></b><sup>1</sup>) of...
<p>(A) Expression of inflammatory cytokines. The mRNAs were analyzed by real-time RT-PCR (left panel...
<p>Total liver transcript levels of (<b>A</b>) <i>fasl</i>, (<b>B</b>) <i>trail</i>, (<b>C</b>) <i>t...
<p>(<b>A–B</b>) Representative histological liver samples from WT and <i>tlr3</i><sup>−/−</sup> mice...
<p>(<b>A</b>) Quantitative real-time PCR (TaqMan) was performed to measure the transcript levels of ...
<p>Fold changes in the levels of Ifnγ (A), Tnfα (B), Il6 (C) and Il10 (D) with time in APAP treated ...
<div><p>Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepa...
<p>(<b>A</b>) Phosphorylation of JNK in liver samples was measured after APAP. Liver lysates of WT a...
<p>Plasma TNF-α levels (A) and hepatic MPO activities (B) were determined at 8 h after APAP exposure...
Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxici...
Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxici...
<p>(A) Level of anti-nuclear autoantibody (ANA) in serum from wild type (WT) and Cdc42<sup>−/−</sup>...
<p><b>A</b>) TUNEL staining revealed apoptotic cells among hepatocytes and lymphocytes in liver from...
<p>Total GSH amounts (A), malonaldehyde amounts (B) and hematoxylin and eosin staining (C) of livers...
International audienceTLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrot...
<p>FTIR spectra (950 cm<b><sup>−</sup></b><sup>1</sup> to 1200 cm<b><sup>−</sup></b><sup>1</sup>) of...
<p>(A) Expression of inflammatory cytokines. The mRNAs were analyzed by real-time RT-PCR (left panel...
<p>Total liver transcript levels of (<b>A</b>) <i>fasl</i>, (<b>B</b>) <i>trail</i>, (<b>C</b>) <i>t...
<p>(<b>A–B</b>) Representative histological liver samples from WT and <i>tlr3</i><sup>−/−</sup> mice...
<p>(<b>A</b>) Quantitative real-time PCR (TaqMan) was performed to measure the transcript levels of ...
<p>Fold changes in the levels of Ifnγ (A), Tnfα (B), Il6 (C) and Il10 (D) with time in APAP treated ...
<div><p>Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepa...
<p>(<b>A</b>) Phosphorylation of JNK in liver samples was measured after APAP. Liver lysates of WT a...
<p>Plasma TNF-α levels (A) and hepatic MPO activities (B) were determined at 8 h after APAP exposure...
Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxici...
Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxici...
<p>(A) Level of anti-nuclear autoantibody (ANA) in serum from wild type (WT) and Cdc42<sup>−/−</sup>...
<p><b>A</b>) TUNEL staining revealed apoptotic cells among hepatocytes and lymphocytes in liver from...
<p>Total GSH amounts (A), malonaldehyde amounts (B) and hematoxylin and eosin staining (C) of livers...
International audienceTLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrot...
<p>FTIR spectra (950 cm<b><sup>−</sup></b><sup>1</sup> to 1200 cm<b><sup>−</sup></b><sup>1</sup>) of...
<p>(A) Expression of inflammatory cytokines. The mRNAs were analyzed by real-time RT-PCR (left panel...