The healing pattern of the wounds in different conditions.

<p>(A) Scaffold treated and (B) injury wound after 0, 1, 2, 3, 4, 5, 7 and 10 days after injury. The wound healing efficacy of the scaffold was evaluated in a full thickness wound model. Following anaesthetized a full thickness excisions of 2 cm in diameter were created by a surgical knife of male Wistar rats. For treatment group after excision was made, the scaffold was covered on the wound immediately. For injury group wounds were not covered for comparison. From the first day after injury, the healing of wound from injury group was slower than scaffold treated wound until 10 days after injury. Scale bar = 0.5 cm. (C) Wound contraction ratios of scaffold and injury at different times. By examining the wound area at definite days, the reduction of wound area was calculated. The surface area of the excisional wounds was calculated as described in methods. The wound area decreased rapidly in the presence of scaffold when compared with the control since first day after injury. The wound area in control group was 60% of the original size on day 7. This percentage was reached almost 3 days earlier at scaffold group. The difference between wounds of injury and scaffold group were statistically significant at day 10. Data are presented as the mean ± standard error.