Murine T cell lymphoma showed active redox circuits as compared to normal lymphocytes.

<p>(A) Intracellular GSH levels were measured by conventional enzyme cycling method <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065929#pone.0065929-Rahman1" target="_blank">[41]</a> at 2, 6, 12 or 24 h post irradiation (4 Gy) in normal lymphocytes and EL-4 lymphoma cells. Bar graph represents GSH/GSSG ratio in normal murine splenic lymphocytes and EL-4 cells. Data points represent mean±S.E.M. from nine replicates from three independent experiments. *p<0.05 as compared to untreated lymphoma cells (B) Thioredoxin activity in wild type EL-4 cells at 2, 6, 12 & 24 h post irradiation (4 Gy) was measured. Bar diagram shows thioredoxin activity in EL-4 cells. Each bar shows mean±S.E.M from nine replicates from three independent experiments. *p<0.01 as compared to untreated lymphoma cells.