Overexpression of <i>TUSC1</i> reduces cell growth and tumorigenicity of lung cancer cells.

<p>(A, B) <i>In vitro</i> cell growth of cancer cell lines (Nu6-1 and H290) transfected with <i>TUSC1</i>. (C, D) Tumor volume of subcutaneously injected stably transfected cancer cells with <i>TUSC1</i> in nude mice <i>in vivo</i>. Restoration of <i>TUSC1</i> expression in cell lines with <i>TUSC1</i> homozygous deletion suppressed cell growth and tumor development compared to the parental cell lines transfected with the empty vector (p<0.05 ).