The time course of body weight (BW) and total adipose tissue (tAT) percentage of BW.

<p>At the age of 5 week, BW was comparable between db/db mice and lean control. Db/db mice older than 6W had higher BW than lean control (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065543#pone-0065543-g001" target="_blank">Figure 1A</a>). At each time point, tAT(all AT from epididymal, perirenal and abodomal) percentage of body weight(BW) from db/db mice were significantly higher than lean control(<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065543#pone-0065543-g001" target="_blank">Figure 1B</a>), indicating that fat tissue mass increased markedly in db/db mice from 5 weeks old.*P<0.01,compared with lean control at the same age.