Results of the oral glucose tolerance test.

<p>Mean plasma concentrations of glucose (<b>A</b>) and insulin (<b>B</b>) during a 75-g oral glucose tolerance test, and (<b>C</b>) the homeostasis model assessment index of insulin resistance (HOMA-IR) in lean (<i>n</i> = 9) and obese (<i>n</i> = 9) men prior to and following 12-wk endurance training. (<b>A</b>) <i>P</i> = 0.04 and <i>P</i> = 0.28 for the comparison of the areas under the curve for glucose (AUC_glucose) of lean and obese men, pre- and post-training, respectively. 2-hr plasma glucose concentration: *<i>P</i>≤0.01 lean <i>vs.</i> obese pre-training; † <i>P</i>≤0.01 pre- <i>vs.</i> post-training (main effect). (<b>B</b>) <i>P</i> = 0.02 and <i>P</i> = 0.02 for the comparison of the areas under the curve for insulin (AUC_insulin) of lean and obese men, pre- and post-training, respectively. Fasting plasma insulin concentration: *<i>P</i>≤0.03 lean <i>vs.</i> obese pre-training; 2-hr plasma insulin concentration: ^†<i>P</i>≤0.02 lean <i>vs.</i> obese pre-training; ^‡P = 0.07 pre- <i>vs.</i> post-training (main effect). (<b>C</b>) HOMA-IR was 68% higher in the obese <i>vs.</i> lean men pre-training and decreased by 17% post-training. *<i>P</i>≤0.02 lean <i>vs.</i> obese pre-training; <i>P</i> = 0.10 pre- <i>vs.</i> post-training (main effect).