<i>S. pneumoniae</i> invasion of endothelial cells is mediated by clathrin and caveolae dependent mechanisms.

<p>Invasion in the presence of the vehicle of the inhibitor is set at 100%, and invasion in experimental conditions is related to this percentage. O designates the relative invasion in one individual experiment, ― is the average of all experiments. A: HBMEC cells treated with clathrin mediated endocytosis inhibitors Amantadine, Sucrose, and, Chlorpromazine (n = 6, 6 and 4 respectively). B: HBMEC treated with caveolae- mediated endocytosis inhibitors PMA, and Nystatin (n = 6 and 6). p.<0.05 in all experiments. Invasion is defined as the number of invading bacteria divided by adhered bacteria.