CQ treatment reduces the severity of EAE.

<p>(A) Briefly, mice were treated with chloroquine for five consecutive days and three days after the last dose of the drug EAE was induced through the administration of MOG_35–55 peptide emulsified in CFA and two injections of Ptx (200 ng/animal) at 0 and 48 h post antigen inoculum. (B and C) The weight change and clinical score were checked routinely. Results are expressed as mean ± SEM for at least five animals. p<0,01 (**) and p<0,005 (***). (D) At 14 days, mice were killed and spinal cords were prepared for histological analysis (H&E stained) to evaluate cellular infiltration in the CNS. The figures are representative of at least three independent experiments performed in different days. Bar: 500 µm.