In vivo CD40 expression after LPS stimulus and Chol-siRNA.

<p>A) ) Kinetic of CD40 expression in liver and kidney after LPS injection, a peak of CD40 expression at 4 h was seen. There were no differences using scrambled siRNA. B) Pharmacodynamic evaluation of Chol-siRNA. Mice receiving a single dose of Chol-siRNA at day 0 and a single injection of LPS at pre determined time points showed reduction on liver and kidney CD40 gene expression. Data are expressed as mean± SEM of four separate experiments.