Steady state ATP levels are more sensitive to <i>HK2</i> suppression in H460 than HCT116 cells, but knockout of <i>ADPGK</i> has no effect in either.

<p>ATP was measured 2 days after transfection with control siRNA or <i>HK2</i> siRNA, following re-seeding in fresh medium for 6 h under normoxia (ox) or anoxia (anox). Values are mean and SEM for 3 biological replicates. Asterisks indicate significance (p&lt;0.05) of <i>HK2</i> siRNA treated vs. siRNA control treated cells. Hash indicates p&lt;0.05 for difference between anoxic vs. normoxic conditions.