Summary of the somatic mtDNA mutations found in 300 oral cavity squamous cell carcinomas.

<p>(A) The spectrum of somatic mutations in the whole mtDNA genome (produced using CGView). Tracked on the circularized mtDNA genome, from outer-most to inner-most, the information indicated is regions of the mtDNA genome, somatic mutations show as green ticks (nucleotide position of mutation hotspots were marked with *), pathogenic somatic mutations show as pink ticks, and GC content. (B) Distribution of the 645 somatic mutations across the various different regions of the mtDNA genome. (C) Mutation types of the 645 somatic mutations. (D) Distribution of somatic mutation shifting pattern by region across the mtDNA genome and the defined pathogenic mutations. HT: heteroplasmy; HM: homoplasmy.