Sesquiterpene lactones inhibited the invasion potential.

<p>Costunolide and dehydrocostus lactone pre-treated DiI stained STS cells were seeded in the upper compartment of matrigel coated 8 µm pore size HTS FluoroBlok™ cell culture inserts in serum free medium. Invasion towards the lower compartment containing medium supplemented with 5% FBS was monitored by fluorescent microscope and quantified after overnight incubation at 37°C. The invasion potential was significantly reduced in all three STS cell lines.