Naturally arising antigenic variations in the VY8 epitope.

<p>(<b>A</b>) Graphical representation showing the frequency of amino acid residues within the VY8 epitope in subtype B Nef sequences retrieved from the Los Alamos database (n = 1191). WebLogo 3 was used to generate the graphic. (<b>B</b>) The frequency of consensus (subtype B) and variant amino acid residues at each position of the VY8 epitope is shown for autologous plasma viral sequences derived from a total of 336 HIV-1-infected individuals, segregated according to <i>HLA-B^*35∶01</i> status. Statistical analysis was performed using Fisher’s exact test. <i>n.s</i>., not significant.