Diagram of integrin (ITGA5 and ITGAV) and SRC signaling pathways.

<p>Shown are AhR signaling, the NRF2-mediated oxidative stress response, and the NLRP3 inflammasome activation pathway regulated by ITGA5/ITGAV and SRC axis. Up-regulated genes downstream of ITGA5/ITGAV and SRC were linked to these three identified signaling pathways with data only displayed from BCG infection. For details on gene abbreviations and fold changes compared with control, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065128#pone.0065128.s003" target="_blank">Table S3</a>. The network is graphically represented as nodes (gene products) and edges (the biological relationship between nodes). Red-shaded nodes represent up-regulated genes.