Depletion of TEM4 and RhoC causes accumulation of enlarged focal adhesions.

<p>(A) Focal adhesions in NS control, TEM4- and RhoC-depleted HUVECs were visualized by staining with paxillin and phalloidin. The whole cell and an isolated area of the leading edge are shown. Scale bar, 10 µm. (B, C) Depletion of TEM4 or RhoC leads to an increase in a total number of FAs (B) and number of large FAs (C). Data are mean ± s.e.m. measured in 10 cells in two independent experiments.