Illustration of challenges associated with nuclei segmentation in heterogeneous tissue.

<p>The original image was created by blending different regions of a tumor (T), muscle (M), adipose (A), and tumor+muscle (T+M) image together. This image was put through SCA to yield the spatial, DCT, and curvelet outputs. Then, the spatial image was false colored green and laid on top of the curvelet image to yield to spatial curvelet overlay. This illustrates how the nuclei are spatially co-registered with some of the features isolated in the curvelet output. This information could be used diagnostically to indicate that these nuclei are associated with benign adipose tissue, not with malignant tissue.