Anti-proliferative activity of CDRI-85/287 in ER-negative breast cancer cells.

<p>(A) Structure and molecular formula of CDRI-85/287. (B) CDRI-85/287 suppresses the growth of ER-negative and EGFR over-expressing breast cancer cells MDA-MB231 and primary breast adenocarcinoma cells. Cells were treated with indicated concentrations of compound for 48h in the absence or presence of 100 ng/ml of EGF. Cell viability was measured using MTT cell viability assay. The percentage of viable cells was calculated as the ratio of treated cells to the control cells. Results are expressed as mean ± SEM, n = 5. p values are a-p<0.001, b<0.01, c-p<0.05 and d-p>0.05 vs. control and e-p<0.001, f-p<0.01, g-p<0.05, h-p>0.05 vs. EGF.