Schematic presentation of DRM-associated internalization of PSMA.

<p>PSMA is transported to the Golgi where it associates with Lubrol WX-DRMs. Likewise, homodimeric forms as well as cell surface forms of PSMA associate with similar type of DRMs at the cell surface. Antibody-induced cross-linking of PSMA homodimers results in a partitioning of PSMA and α-tubulin into Triton X-100-DRMs. Concomitantly internalization of PSMA occurs along α-tubulin filaments.