Chromosomal mutants altering Pol I constructed for this study.

<p>Blue and white segments indicate the N-terminal domain, consisting of residues 1–323 and harboring the 5’-to-3’ exonuclease; and the C-terminal domain, consisting residues 324–928 and harboring the 3’-to-5’ exonuclease and DNA polymerase, respectively. The sequence of the <i>polA-split</i> mutation is indicated below the map; below that is the relevant segment of the wild type sequence.