Increased colonic injury in DSS treated<i>Mttp-IKO</i> mice.

<p><b>A</b>. Decreased survival of <i>Mttp-IKO</i> (n = 10) versus littermate controls (n = 12). 8–10 weeks mice were fed 2.5% DSS in drinking water for 12 days and followed up to 25 days. **p<0.01. <b>B</b>. Weight recovery curve after one cycle of DSS. Mice (n = 4 mice per group) were fed 2.5% DSS for 7 days and weighed every 1–3 days up to 25 days after the 1^st day of DSS treatment. *p<0.05. <b>C</b>. Weight loss after 7days DSS treatment, n = 10–12 mice per genotype. Data are presented as mean% ± SEM of initial weight. *p<0.05, **p<0.01 <b>D</b>. Representative images of gross appearance of colon from control and <i>Mttp IKO</i> mice after 7 days DSS treatment. <b>E</b>. Colon length at 0, 5 and 7 days on 2.5% DSS. Data are mean ± SE of 4–9 mice per group.*p<0.05.