CpG-ODN regulates the expression of caspase-3 after IR.

<p>Mice were treated with CpG-ODN and euthanized at 48 hours after 8 Gy of IR. Samples were assessed by immunohistochemistry. (A) Representative photomicrographs showing caspase-3 positive cell (arrowed), (B) positional distribution of caspase-3 positive cell, (C) the number of caspase-3 positive cell at position 4, and (D) the mean of caspase-3 positive per crypt. (n = 3/group in each of three separate experiments, with 3 section per mice, data are represented by the mean ±SEM. *p<0.05 for differences between IR plus CpG-ODN and IR control groups).