Nissl’s staining of AQP4^+/+ and AQP4^−/− mice.

<p>Injection of rhVEGF165 intracerebroventricularly had no effect on Nissl’s staining in normal mice. At the three time points, marked neuron loss perihemotoma were found in AQP4^−/− mice when compared to AQP4^+/+ mice. Besides, rhVEGF165 increased perihemotomal Nissl’s staining cells in both AQP4^+/+ and AQP4^−/− mice. (A) Groups of control, control plus VEGF and sham operation at 3 d. (B) Groups of ICH and ICH plus VEGF at 1 d, 3 d and 7 d. Astericks represent the hemotoma zones. Scale bar: 50 µm.