Optical coherence tomography and histological sections from WT and <i>CFB ^−/−</i> mice following CE.

<p>Posterior poles from WT (<b>A</b>–<b>D</b>) and AP-deficient (<b>E</b>–<b>H</b>) mice were analyzed <i>in vivo</i> using OCT (<b>A,B</b> and <b>E,F</b>) and <i>ex vivo</i> using histology (<b>C,D</b> and <b>G,H</b>), comparing cigarette smoke (CE) and control conditions. OCT measurements were taken ∼0.5 mm from the optic nerve head in the nasal quadrant. There is visible thinning of the ONL (red) and INL (blue) in WT animals that is absent in <i>CFB ^−/−</i> mice. Light microscopy performed on epoxy sections of central retina, derived from WT and <i>CFB ^−/−</i> animals, supports the thinning observed in OCT images for WT mice exposed to smoke.