Analysis of parasite reduction ratio at 48 h (PRR_48h).

<p>Evaluation of PRR_48h allowed validation of the <i>Plasmodium berghei</i> ED₉₀-normalized in vivo assay in vehicle-treated control animals and against human data. (A) Correlation between the log₁₀ [PRR_48h] and the distance between top and bottom values of the logistic fit calculated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066967#pone-0066967-g004" target="_blank">Figure 4</a> for each control antimalarial in CD1 mice infected with <i>P. berghei</i>. (B) Correlation of log₁₀ [PRR_48h] between CD1 mice infected with <i>P. berghei</i> in the screening assay format and humans infected with <i>P. falciparum</i>. Data on log₁₀ [PRR_48h] in humans are taken from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066967#pone.0066967-Anvikar1" target="_blank">[30]</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066967#pone.0066967-Sanz1" target="_blank">[32]</a>.