IBA1 positive microglia increase and have an activated morphology in prion animals.

<p>a–d) Compared to the sparse, uniform distribution of microglia in NBH animals, the lateral septum, dorsal part, shows an increased expression in the prion strains (4a vs. 4b-d). e–h) CA1 of the hippocampus shows a large increase of microglia with activated morphology (insets) in the ME7 and 79A strains, with a more modest increase in the 22L strain (4e vs. 4f-h). i-l): The median raphe has increased microglia in all strains (4i vs. 4j-l). m–p) microglia levels were similar in all treatment groups. Scale bars = 100 µm.