Main groups of gene expression profiles obtained over the BW720c time course.

<p>Profiles were derived from pairwise comparisons, BL20 vs TBL20; TBL20 vs TBL20_BW720c_24 h; TBL20_BW720c_24 h vs TBL20_BW720c_48 h as defined using RP with 5% FDR. The total number of differentially expressed genes in TBL20 compared to BL20 was 3,079. In addition to those genes exhibiting reversal in expression at 24 h, a further 303 (10%) showed reversal in the parasite induced expression profile at 48 h. We cannot distinguish whether these represent delayed reversal due to parasite death and hence associated with Group 2 or an apoptosis associated switch in expression of a gene that is non-responsive to parasite death (Group 3). Within Group 4, 30% showed enhancement in original parasite induced expression at 48 h only. Predominant trend in direction of expression in the group, solid line; alternative direction trend in the group, dashed line.