The effects of the ratios of IGF-I, IGF-II and insulin on normalized steady-state IGF-IR complex concentration.

<p>The calculated complex concentrations are normalized to total receptor concentration (<i>i.e. c_RT0</i> = 0.6 nM). Free IGF half-life = 20 min, free IGFBP half-life = 100 min, mass transfer coefficient <i>k_BP</i> = <i>k_SC</i> = 5.5×10⁻⁸ m/s, and = 0.066 nM.