RyRs do not contribute to calcium signal due to T type calcium channels.

<p>A) Representative trace showing the inhibition of 30 mM HiK response by NiCl₂ (200 µM). B) Pooled results showing inhibition of the 30 mM HiK response by NiCl₂ (200 µM) (n = 7, **p = 0.001). C) Representative trace showing that ryanodine does not affect the calcium influx due to opening T type channels with a small depolarization. D) Pooled results showing no significant inhibition of the 30 mM HiK response by ryanodine (20 µM) (n = 5, p = 0.27).