Mapping with functional mAbs identifies an epitope in domain D3.
- Annalisa Nuccitelli (342679)
- C. Daniela Rinaudo (120751)
- Barbara Brogioni (427603)
- Roberta Cozzi (120732)
- Mario Ferrer-Navarro (427086)
- Daniel Yero (427087)
- John L. Telford (120748)
- Guido Grandi (120744)
- Xavier Daura (427091)
- Martin Zacharias (9025)
- Domenico Maione (120753)
Publication date
June 2013
DOIAbstract
<p>(A) Mass spectrum obtained for the LysC digestion of BP-2a (upper panel) and peptides immunocaptured by mAb 4H11/B7 (lower panel). (B) Sequences corresponding to the immunocaptured peptides (2946.530 Da and 4156.461 Da). (C) Detail of the identified epitope in the structure; in yellow the identified peptide and in red the surface representation of the identified peptide. Note that the segment Glu424 to Lys436 is the most accessible one.</p
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