Comparison of the effect between LY2157299 and the fully humanized monoclonal antibody D10 in HCC cell migration.

<p>LY2157299 and D10 were tested in two different HCC cell lines, (A) HepG2 and (B) HLE, that were allowed to migrate on collagen I or matrigel. LY2157299, but not D10, was able to inhibit cell migration of both cell lines on both extracellular matrix components. An anti-isotype IgG was used as internal negative control. Results of representative experiments are shown, and values are expressed as mean ± standard deviation. *P<0.05 **P<0.001 versus TGF-β1.