Comparison of the effect of two TGF-βR inhibitor analogs, LY2109761 and LY2157299, on HCC cell migration on different extracellular matrix components.

<p>(A) HLE and (B) HLF cells were allowed to migrate for 16 hours on fibronectin (Fn), vitronectin (Vn), laminin-5 (Ln-5) and fibrinogen (Fg) in the presence or absence (vehicle) of increasing concentrations of LY2109761 or LY2157299. All conditions were performed in duplicate, and each experiment was repeated at least three times. Results of representative experiments are shown, and values are expressed as mean ± standard deviation.