<div><p>Rab37 belongs to a subclass of Rab GTPases regulating exocytosis, including also Rab3a and Rab27a. Proteomic studies indicate that Rab37 is associated with insulin-containing large dense core granules of pancreatic β-cells. In agreement with these observations, we detected Rab37 in extracts of β-cell lines and human pancreatic islets and confirmed by confocal microscopy the localization of the GTPase on insulin-containing secretory granules. We found that, as is the case for Rab3a and Rab27a, reduction of Rab37 levels by RNA interference leads to impairment in glucose-induced insulin secretion and to a decrease in the number of granules in close apposition to the plasma membrane. Pull-down experiments revealed that, despite similar ...
RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proli...
The putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting, RT-PCR...
BACKGROUND: RalA and RalB are multifuntional GTPases involved in a variety of cellular processes inc...
Rab37 belongs to a subclass of Rab GTPases regulating exocytosis, including also Rab3a and Rab27a. P...
Rab37 belongs to a subclass of Rab GTPases regulating exocytosis, including also Rab3a and Rab27a. P...
SUMMARYInsulin secretion from pancreatic beta-cells is a fundamental condition for the maintenance o...
The small GTPase Rab27a, along with the isoforms of Rab3, is present on insulin secretory granules a...
Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells IEZZ...
Insulin-secreting cells express four GTPases of the Rab3 family. After separation of extracts of INS...
Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily regulate glucose-...
The stimulus-response coupling pathway for glucose-reg-ulated insulin secretion has implicated a ris...
The small GTPases Rab3 and Rab27 are associated with secretory granules of pancreatic beta-cells and...
AbstractThe putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting...
RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proli...
Background: RalA and RalB are multifuntional GTPases involved in a variety of cellular processes inc...
RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proli...
The putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting, RT-PCR...
BACKGROUND: RalA and RalB are multifuntional GTPases involved in a variety of cellular processes inc...
Rab37 belongs to a subclass of Rab GTPases regulating exocytosis, including also Rab3a and Rab27a. P...
Rab37 belongs to a subclass of Rab GTPases regulating exocytosis, including also Rab3a and Rab27a. P...
SUMMARYInsulin secretion from pancreatic beta-cells is a fundamental condition for the maintenance o...
The small GTPase Rab27a, along with the isoforms of Rab3, is present on insulin secretory granules a...
Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells IEZZ...
Insulin-secreting cells express four GTPases of the Rab3 family. After separation of extracts of INS...
Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily regulate glucose-...
The stimulus-response coupling pathway for glucose-reg-ulated insulin secretion has implicated a ris...
The small GTPases Rab3 and Rab27 are associated with secretory granules of pancreatic beta-cells and...
AbstractThe putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting...
RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proli...
Background: RalA and RalB are multifuntional GTPases involved in a variety of cellular processes inc...
RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proli...
The putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting, RT-PCR...
BACKGROUND: RalA and RalB are multifuntional GTPases involved in a variety of cellular processes inc...