rESAT-6-CFP10-induced changes in the ratio of the proportion of T cells expressing IFN-γ/IL-4 in tuberculosis patients.

<p>PBMC obtained from 10 active TB patients and were cultured in the presence of rESAT-6-CFP10. Cells were then stained to detect the presence of intracellular IFN-γ and IL-4. The ratio of the proportion of CD4⁺ (A) and CD8⁺ (B) T cells expressing IFN-γ/IL-4 for individual patients at diagnosis and during follow up are represented. The significant p-values obtained from the Friedman’s test with Dunn’s post-test correction for the mean ratios were 0.0017 at T2 v T0 and 0.001 at T3 v T0 in CD4⁺ T cells and 0.0022 at T3 v T0 in CD8⁺ T cells. Abbreviations are described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068121#pone-0068121-g001" target="_blank"><b>Figure 1</b></a>.